Cecilia Hegardt PubFacts

Publications PHI - Phase Holographic Imaging

Synthetic strategies for modification of each of the directly accessible functional groups of salinomycin are presented and the resulting library of analogues was investigated to establish structure–activity relationships, both with respect to cytotoxicity and phenotype selectivity in breast cancer cells. 20-O-Acylated derivatives stand out by exhibiting both improved selectivity and activity. 2017-04-01 · The X-ray structure of salinomycin-salicylhydroxamic acid conjugate (11b). The antiproliferative activities of salinomycin-hydroxamic acid conjugates were evaluated in HT-29 colorectal cancer, HGC-27 gastric cancer and triple-negative MDA-MB-231 breast cancer cells using MTT assay ( Table 1 ). Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug. Salinomycin has been shown by Piyush Gupta et al. of the Massachusetts Institute of Technology and the Broad Institute to kill breast cancer stem cells in mice at least 100 times more effectively than the anti-cancer drug paclitaxel.

Salinomycin structure

In light of its biological activity coupled with the physicochemical properties and spectral data, the antibiotic is assumed to belong This information is only displayed if the substance is well-defined, its identity is not claimed confidential and there is sufficient information available in ECHA’s databases for ECHA’s algorithms to generate a molecular structure. More help available here. EC / List no.: 258-290-1. CAS no.: 53003-10-4. Mol. formula: C42H70O11 The parent hydroxamic acid, salinomycin-NHOH, forms both inclusion complexes and well-defined electroneutral complexes with potassium and sodium cations via 1,3-coordination by the hydroxamic acid moiety to the metal ion. Salinomycin. 2 Product Results.

Crystal structure of salinomycin allyl amide acetonitrile solvate. The relative affinity of salinomycin for complex formation with various cations decreases in the order K + > Na + > Cs + > Sr 2+ > Ca 2+ , Mg 2+ .

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Molecular Weight: 751.00. CAS Number: 53003-10-4.

Publications

12 okt. 2016 — in hydraulic structures – interactions between water absorption, Björn Borgström: ”Salinomycin analogs: Mechanistic probes and structure 5 nov. 2013 — Design, Synthesis, and Evaluation of Salinomycin Analogs Towards The FET family of Proteins in Sarcomas – Structure, Cell biology, 29 sep. 2018 — Cell biology studies cells – their physiological properties, structure, the Ämnet Salinomycin som Sofia har använt vid forskningen anses som 7 dec. 2015 — tss | wetland reactor | salinomycin | konczewicki | milk house wastewater server | protein structure prediction | protein structure | brachyspira Domain boundaries of salinomycin synthase module 7 Figure S5. SWISS-MODEL1 ( protein structure homology-models of KR0 domains from polyether reactor | salinomycin | konczewicki | milk house wastewater | cobalt | australis protein structure prediction | protein structure | brachyspira | scop | structure med foderantibiotika (klortetracyklin 50 g per ton, salinomycin 50 g per ton) för att förbättra Uncovering the composition of microbial community structure and ämnen. , Negativa effekter; , Cancer stamceller; , Celldöd; , Perifera neuropatier.

The ionophore salinomycin exerts selective activity against cancer stem cells. Synthetic strategies for modification of the directly accessible functional groups of this structure are explored, and a set of activity domains are identified by biological assays. Salinomycin Hydroxamic Acids: Synthesis, Structure, and Biological Activity of Polyether Ionophore Hybrids Borgström, Björn LU ; Huang, Xiaoli LU ; Chygorin, Eduard ; Oredsson, Stina LU and Strand, Daniel LU ( 2016 ) In ACS Medicinal Chemistry Letters 7 (6) . p.635-640 Synthetic strategies for modification of each of the directly accessible functional groups of salinomycin are presented and the resulting library of analogues was investigated to establish structure–activity relationships, both with respect to cytotoxicity and phenotype selectivity in breast cancer cells.
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of our undergraduates enter employment or further study shortly after graduating (HESA 2016/17) Using a structure estimation method based on molecular connectivity indices(1), the Koc of salinomycin can be estimated to be 6050(SRC).

The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists. Structure.
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PDF | Salinomycin diastereoisomers and their benzoylated derivatives were synthesized and evaluated with both antiproliferative activities and | Find, read and cite all the research you need on IC50: 7.7, 13.7 and 10.4 μM for HepG2, SMMC-7721 and BEL-7402 cell line, respectively (after 24h treatment) Salinomycin (Sal), which is a polyether ionophore antibiotic from Streptomyces albus, has been proven to be able to kill different types of human The ionophore salinomycin selectively targets cancer stem cells. Synthetic strategies for modification of each of the directly accessible functional groups provide activity domains with respect to cy (A) Chemical structure of salinomycin. (B) MTT dose‑response curves in JIMT‑1 cells for salinomycin without modification.

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Jump to navigation Jump to search. File; File history; File usage on Commons; However, two salinomycin derivatives (salinomycin n-butyl amide and salinomycin 2,2,2-trifluoroethyl ester) were identified that showed increased anti-trypanosomal activity with 50 % growth inhibition values in the mid nanomolar range and minimum inhibitory concentrations of below 1 μM similar to suramin, a drug used in the treatment of sleeping sickness. Salinomycin sodium salt Chemical Structure. CAS NO. 55721-31-8. Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug. Availability: In stock.